충남대학교 약학대학 제제설계학실

Formulation Design & Development Laboratory, College of Pharmacy, Chungnam National University
Associate Professor Jae-Young Lee

About Us

본 연구실은 약제학을 기반으로 한 제제설계학 연구실입니다. 주요 연구 분야는 고분자, 단백질, 지질 등 다양한 생체유래 혹은 생체친화 물질을 기반으로 한 나노약물전달체의 설계, 제조 및 평가입니다. 약물의 종양 표적 전달 및 침투 향상, 제형 기반의 항암화학치료, 광학치료 및 면역치료 요법 개발, 각종 분석 및 평가 등을 하고 있으며 처음 제형설계부터 in vitro 및 in vivo 평가까지 다양한 실험을 배울 수 있습니다. 여러 연구를 통해 우수한 논문들을 꾸준히 게재하고 있고 여러 국책과제에도 참여 중이며 다양한 국내 제약사와 협업을 통하여 전임상 및 임상과정까지도 직·간접적으로 참여하고 있습니다.

Research Topics

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제형설계를 통한 나노입자의 제조 및 평가

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HPLC 및 LC/MS를 이용한 물질의 분석 및 평가

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생물학적의약품(단백질)의 개발, 분석 및 평가

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경구용 제형의 생체이용률 증진 및 PK study

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난용성 물질의 가용화

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융합단백질의 설계, 발현 및 효능 평가

Selected Publications

Phenylboronic acid-decorated chondroitin sulfate A-based theranostic nanoparticles for enhanced tumor targeting and penetration

Curcumin-loaded lipid-hybridized cellulose nanofiber film ameliorates imiquimod-induced psoriasis-like dermatitis in mice

Lung-selective 25-hydroxycholesterol nanotherapeutics as a suppressor of COVID-19-associated cytokine storm

Hydroxyapatite-binding albumin nanoclusters for enhancing bone tumor chemotherapy

Advisor

Jae-Young Lee (이재영)

PhD, Associate Professor

Tel: 042-821-5935

e-mail: jaeyoung@cnu.ac.kr

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학력 및 경력

연도

학교/기관

전공/직위

학위/비고

2006.03~2011.02

Open

서울대학교 약학대학

약학

학사

2011.02~2016.08

Open

서울대학교 약학대학 대학원

약제학

박사

2016.09~2017.02

Open

서울대학교 종합약학연구소

선임연구원

2017.03~2021.02

Open

충남대학교 약학대학

조교수

2021.03~현재

Open

충남대학교 약학대학

부교수

Members

Lab Members

Alumni

Publications

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Phenylboronic acid-decorated chondroitin sulfate A-based theranostic nanoparticles for enhanced tumor targeting and penetration, Advanced Functional Materials (2015). (first-author) 19.924 / https://doi.org/10.1002/adfm.201500680

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Iodinated hyaluronic acid oligomer-based nanoassemblies for tumor-targeted drug delivery and cancer imaging, Biomaterials (2016). (first-author) 15.304 / https://doi.org/10.1016/j.biomaterials.2016.01.060

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Polyethylene glycol-conjugated chondroitin sulfate A derivative nanoparticles for tumor-targeted delivery of anticancer drugs, Carbohydrate polymers (2016). (first-author) 10.723 / https://doi.org/10.1016/j.carbpol.2016.05.043

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Nanocomposites based on Soluplus and Angelica gigas Nakai extract fabricated by an electrohydrodynamic method for oral administration, Journal of Colloid and Interface Science (2016) (co-author) 9.965 / https://doi.org/10.1016/j.jcis.2016.08.080

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Dual CD44 and folate receptor-targeted nanoparticles for cancer diagnosis and anticancer drug delivery, Journal of Controlled Release (2016). (first-author) 11.467 / https://doi.org/10.1016/j.jconrel.2016.06.021

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Boronic acid-tethered amphiphilic hyaluronic acid derivative-based nanoassemblies for tumor targeting and penetration, Acta Biomaterialia (2017). (co-author) 10.633 / https://doi.org/10.1016/j.actbio.2017.02.030

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Chemosensitizing indomethacin-conjugated chitosan oligosaccharide nanoparticles for tumor-targeted drug delivery, Acta Biomaterialia (2017). (first-author) 10.633 / https://doi.org/10.1016/j.actbio.2017.05.012

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Curcumin-loaded lipid-hybridized cellulose nanofiber film ameliorates imiquimod-induced psoriasis-like dermatitis in mice, Biomaterials (2018). (corresponding-author) 15.304 / https://doi.org/10.1016/j.biomaterials.2018.08.030

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Sprinkle Formulations—A Review of Commercially Available Products, Asian Journal of Pharmaceutical Sciences (2019) (corresponding-author) 9.273 / https://doi.org/10.1016/j.ajps.2019.05.003

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Blood component ridable and CD44 receptor targetable nanoparticles based on a maleimide-functionalized chondroitin sulfate derivative, Carbohydrate Polymers (2019). (first-author) / https://doi.org/10.1016/j.carbpol.2019.115568

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Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm, Biomaterials (2021). (co-author) 15.304 / https://doi.org/10.1016/j.biomaterials.2020.120389

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Chondroitin sulfate-hybridized zein nanoparticles for tumor-targeted delivery of docetaxel, Carbohydrate Polymers (2021). (corresponding-author) 10.723 / https://doi.org/10.1016/j.carbpol.2020.117187

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Lung-selective 25-hydroxycholesterol nanotherapeutics as a suppressor of COVID-19-associated cytokine storm, Nano Today (2021). (corresponding-author) 18.962 / https://doi.org/10.1016/j.nantod.2021.101149

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PEGylated nanoparticle albumin-bound steroidal ginsenoside derivatives ameliorate SARS-CoV-2-mediated hyper-inflammatory responses, Biomaterials (2021). (corresponding-author) 15.304 / https://doi.org/10.1016/j.biomaterials.2021.120827

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Hydroxyapatite-binding albumin nanoclusters for enhancing bone tumor chemotherapy, Journal of Controlled Release (2022). (corresponding-author) 11.467 / https://doi.org/10.1016/j.jconrel.2021.12.039

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Mannosylated poly(acrylic acid)-coated mesoporous silica nanoparticles for anticancer therapy, Journal of Controlled Release (2022). (co-author) 11.467 / https://doi.org/10.1016/j.jconrel.2022.06.064